The Competitive Nature of HOXB4-Transduced HSC Is Limited by PBX1
نویسندگان
چکیده
منابع مشابه
Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo.
Overexpression of HOXB4 in hematopoietic stem cells (HSCs) leads to increased self-renewal without causing hematopoietic malignancies in transplanted mice. The molecular basis of HOXB4-mediated benign HSC expansion in vivo is not well understood. To gain further insight into the molecular events underlying HOXB4-mediated HSC expansion, we analyzed gene expression changes at multiple time points...
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ژورنال
عنوان ژورنال: Immunity
سال: 2003
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(03)00090-6